Affects: Cats, Dogs
Gastric dilatation volvulus (GDV), also known as gastric dilation, twisted stomach, or gastric torsion, is a medical condition that affects dogs and rarely cats and guinea pigs, in which the stomach becomes overstretched and rotated by excessive gas content. The condition also involves compression of the diaphragm and caudal vena cavae. The word bloat is often used as a general term to mean gas distension without stomach torsion (a normal change after eating), or to refer to GDV.
GDV is a life-threatening condition in dogs that requires prompt treatment. It is common in certain breeds; deep-chested and large dog breeds are especially at risk. Mortality rates in dogs range from 10 to 60%, even with treatment. With surgery, the mortality rate is 15 to 33 percent.
Symptoms: Symptoms are not necessarily distinguishable from other kinds of distress. A dog might stand uncomfortably and seem to be in extreme discomfort for no apparent reason. Other possible symptoms include firm distension of the abdomen, weakness, depression, difficulty breathing, hypersalivation, and retching without producing any vomitus (nonproductive vomiting). Many dogs with GDV have cardiac arrhythmias (40% in one study). Chronic GDV in dogs, include symptoms such as loss of appetite, vomiting, and weight loss. Hypovolaemia may occur and in severe cases hypovolaemic shock and hypoperfusion.
Blood dyscrasias have been identified in patients with GDV. Haemological conditions that may be identified include: neutrophilic leukocytosis, lymphopaenia, leukopaenia, thrombocytopaenia, and haemoconcentration. Other conditions include: hepatocelluar damage, cholestasis, azotemia and hypokalaemia.
Causes: Gastric dilatation volvulus is multifactorial without any one cause being identified, but in all cases the immediate prerequisite is a dysfunction of the sphincter between the esophagus and stomach and an obstruction of outflow through the pylorus.
Hypergastrinaemia has been hypothesised as a cause of GDV. Pyloric hypertrophy as a result of hypergastrinaemia was presumed to cause pyloric outflow obstruction, retarding gastric emptying. Studies have not found evidence to support this theory. One study found no association between pyloric hypertrophy and GDV.
Impairment of gastric myoelectricity retarding gastric emptying has been hypothesised as a cause of GDV. Currently no study has identified an association between gastric myoelectricity and GDV.
Risk Factors: Dog breeds that have a higher depth to width ratio of the thorax are significantly more likely to acquire GDV than other breeds. If there is a family history of the condition the risk is even more severe, highlighting a heritability to the predisposing factors. Body weight is a factor with obese dogs being less likely to develop GDV than healthy or underweight dogs.
Diagnosis: A diagnosis of GDV is made by several factors. The breed and history often gives a significant suspicion of the condition, and a physical examination often reveals the telltale sign of a distended abdomen with abdominal tympany. Shock is diagnosed by the presence of pale mucous membranes with poor capillary refill, increased heart rate, and poor pulse quality. Radiographs (X-rays), usually taken after decompression of the stomach if the dog is unstable, shows a stomach distended with gas. The pylorus, which normally is ventral and to the right of the body of the stomach, is cranial to the body of the stomach and left of the midline, often separated on the X-ray by soft tissue and giving the appearance of a separate gas-filled pocket (double-bubble sign).
Treatment: Patients with GDV need to be stabilised as soon as possible. Perfusion and blood pressure need to be normalised before any further treatment can be performed. Analgesia should also be provided.
Patients require intravenous fluid therapy with saline. Colloid fluids may be required if the patient does not respond well to the crystalloid solution. Antiarrhythmic drugs should be administered after starting fluid therapy to stabilise blood pressure. Other drugs such as dobutamine should be provided if blood pressure fails to normalise, only as a last resort. Other vasopressors can be used such as ephedrine, phenylephrine, and epinephrine.
Percutaneous decompression is the easiest method of treating GDV. A large catheter is inserted into the gastric lumen. If done incorrectly the spleen may be lacerated or punctured. Potentially the content of the stomach may leak if the procedure is performed incorrectly.
Orogastric intubation is another method for treatment. An orogastric tube is entered into the stomach via the oesophageal sphincter, tepid water is sent as a bolus through the tube into the stomach to lavage it. Fluid should be regurgitated up the tube. If it is not then a stomach perforation has likely occurred.
Prevention: Recurrence of GDV attacks can be a problem, occurring in up to 80% of dogs treated medically only (without surgery). To prevent recurrence, at the same time the bloat is treated surgically, a right-side gastropexy is often performed, which by a variety of methods firmly attaches the stomach wall to the body wall, to prevent it from twisting inside the abdominal cavity in the future. While dogs that have had gastropexies still may develop gas distension of the stomach, a significant reduction in recurrence of gastric volvulus is seen. Of 136 dogs that had surgery for gastric dilatation-volvulus, six that did have gastropexies had a recurrence, while 74 (54.5%) of those without the additional surgery recurred. Gastropexies are also performed prophylactically in dogs considered to be at high risk of GDV, including dogs with previous episodes or with gastrointestinal disease predisposing to GDV, and dogs with a first-order relative (parent or sibling) with a history of it.
Precautions that are likely to help prevent gastric dilatation-volvulus include feeding small meals throughout the day instead of one big meal, and not exercising immediately before or after a meal.
Prognosis: Immediate treatment is the most important factor in a favorable prognosis. A delay in treatment greater than 6 hours or the presence of peritonitis, sepsis, hypotension, or disseminated intravascular coagulation are negative prognostic indicators. Patients that lack the ability to walk are 4.4 times more likely to die. Comatose patients are 36 times more likely to die. Dogs that show depression when presented are three times more likely to die.
Historically, GDV has held a guarded prognosis. Although "early studies showed mortality rates between 33 and 68% for dogs with GDV," studies from 2007 to 2012 "reported mortality rates between 10 and 26.8%". Mortality rates approach 10 to 40% even with treatment. With prompt treatment and good preoperative stabilization of the patient, mortality is significantly lessened to 10% overall (in a referral setting). Negative prognostic indicators following surgical intervention include postoperative cardiac arrhythmia, splenectomy, or splenectomy with partial gastric resection. A longer time from presentation to surgery was associated with a lower mortality, presumably because these dogs had received more complete preoperative fluid resuscitation, thus were better cardiovascularly stabilized prior to the procedure.